Database : HANSEN Search on : GENOMA BACTERIANO [Subject descriptor] References found : 12 [refine] Displaying: 1 .. 12   in format [Detailed]

page 1 de 1

1 / 12

HANSEN

select to print

Id: 18099 Author: Trautman, J. R; Enna, C. D Title: Leprosy ?- Source: s.l; s.n; s.d. 38p p. ilus. Abstract: Leprosy is a chronic infectious disease of man which, depending on the type of the disease present, affects primarily the peripheral nerves, skin, mucous membranes, eyes, testes, and bone. There are two polar types, viz, lepromatous leprosy, a generalized process, and tuberculoid leprosy, a localized disease. A third type, dimorphous (borderline) leprosy, encompasses features of both polar types, and a fourth type, indeterminate leprosy, is an early, mild, undifferentiated form. Leprosy is often referred to as Hansen's disease. Descriptors: HANSENIASE/clas HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/imunol HANSENIASE/terap HANSENIASE/compl HANSENIASE/prev - GENOMA BACTERIANO  EDUCACAO DO PACIENTE/tend  POLITICA DE SAUDE  SERVICOS DE SAUDE COMUNITARIA Location: BR191.1; 00524/s

2 / 12

HANSEN

select to print

Id: 18098 Author: Engers, H; Morel, C. M Title: Focus: leprosy ..- Source: s.l; s.n; 2002. 2p p. . Descriptors: HANSENIASE/epidemiol HANSENIASE/prev - POLITICA DE SAUDE/tend  GENOMA BACTERIANO Limits: HUMANO Location: BR191.1; 01026/s

3 / 12

HANSEN

select to print

Id: 17691 Author: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Title: The continuing challenges of leprosy ..- Source: s.l; s.n; 2006. 44 p. ilus, tab. Abstract: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descriptors: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limits: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09365/S

4 / 12

HANSEN

select to print

Id: 17688 Author: Geluk, Annemieke; Ottenhoff, Tom H. M Title: HLA and leprosy in the pre and postgenomic eras ..- Source: s.l; s.n; 2006. 7 p. graf. Abstract: Leprosy has intrigued immunologists for many decades. Despite minimal genetic variation between Mycobacterium leprae isolates worldwide, two completely different forms of the disease can develop in the susceptible human host: localized, tuberculoid, or paucibacillary leprosy, which can heal spontaneously, and disseminating, lepromatous, or multibacillary leprosy, which is progressive if untreated. The questions which host factors regulate these very different outcomes of infection, by what mechanisms, and whether these can be used to combat disease remain unanswered. Leprosy has been one of the very first human diseases in which human leukocyte antigen (HLA) genes were demonstrated to codetermine disease outcome. Jon van Rood was among the earliest researchers to recognize the potential of this ancient disease as a human model to dissect the role of HLA in disease. Decades later, it is now clear that HLA molecules display highly allele-specific peptide binding capacity. This restricts antigen presentation to M. leprae-reactive T cells and controls the magnitude of the ensuing immune response. Furthermore, specific peptide/HLA class II complexes can also determine the quality of the immune response by selectively activating regulatory (suppressor) T cells. All these factors are believed to contribute to leprosy disease susceptibility. Despite the global reduction in leprosy disease prevalence, new case detection rates remain invariably high, demonstrating that treatment alone does not block transmission of leprosy. Better tools for early detection of preclinical M. leprae infection, likely the major source of unidentified transmission, therefore is a priority. Newly developed HLA-based bioinformatic tools now provide novel opportunities to help combat this disease. Here, we describe recent work using HLA-DR peptide binding algorithms in combination with recently elucidated genome sequences of several different mycobacteria. Using this postgenomic HLA-based approach, we were able to identify 12 candidate genes that were unique to M. leprae and were predicted to contain T cell epitopes restricted via several major HLA-DR alleles. Five of these antigens (ML0576, ML1989, ML1990, ML2283, ML2567) were indeed able to induce significant T cell responses in paucibacillary leprosy patients and M. leprae-exposed healthy controls but not in most multibacillary leprosy patients, tuberculosis patients, or endemic controls...(AU). Descriptors: Motivos de Aminoácidos Anticorpos Antibacterianos/BL Antígenos de Bactérias/IM Sítios de Ligação Epitopos de Linfócito T Genes Classe II do Complexo de Histocompatibilidade (MHC) Genoma Bacteriano Glicolipídeos/IM Antígenos HLA-DR/*GE/IM Hanseníase/DI/*IM/MI Hanseníase Virchowiana/DI/IM/MI Hanseníase Tuberculóide/DI/IM/MI Mycobacterium leprae/GE/*IM Linfócitos T/IM/MI Limits: HUMANO Research Support, Non-U.S. Gov´t Location: BR191.1; 09362/S

5 / 12

HANSEN

select to print

Id: 17558 Author: Monot, Marc; Honore, Nadine; Garnier, Thierry; Araoz, Romulo; Coppee, Jean-Yves; Lacroix, Celine; Sow, Samba; Spencer, John S; Truman, Richard W; Williams, Diana L; Gelber, Robert; Virmond, Marcos; Flageul, Beatrice; Cho, Sang-Nae; Ji, Baohong; Paniz-Mondolfi, Alberto; Convit, Jacinto; Young, Saroj; Fine, Paul E; Rasolofo, Voahangy; Brennan, Patrick J; Cole, Stewart T Title: On the origin of leprosy ..- Source: s.l; s.n; May 2005. 3 p. ilus, mapas, tab, graf. Abstract: Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years. (AU). Descriptors: Genoma Bacteriano Sequências Repetitivas Dispersas Hanseníase/EP/*HI/MI/TM Mycobacterium leprae/CL/*GE Limits: Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Humanos História do Século 18 História do Século 19 História Antiga Location: BR191.1; 09337/s

6 / 12

HANSEN

select to print

Id: 12841 Author: Vissa, Varalakshmi D; Brennan, Patrick J Title: The genome of Mycobacterium leprae: minimal mycobacterial gene set ..- Source: s.l; s.n; 2001. 8 p. ilus. Descriptors: membrana celular evolução molecular genoma bacteriano mycobacterium leprae Location: BR191.1; 08933/s

7 / 12

HANSEN

select to print

Id: 12123 Author: Cole, S. T; Eigimeier, K; Parkhill, J; James, K. D; Thomson, N. R; Wheeler, P. R; Honore, N; Garnier, T; Churcher, C; Harris, D; Mungall, K; Basham, D; Brown, D; Chillingworth, T; Connor, R; Davies, R. M; Devlin, K; Duthoy, S; Feltwell, T; Fraser, A; Hamlin, N; Holroyd, S; Hornsby, T; Jagels, K; Lacroix, C; Maclean, J; Moule, S; Murphy, L; Oliver, K; Quail, M. A; Rajandream, M.-A; Rutherford, K. M; Rutter, S; Seeger, K; Simon, S; Simmonds, M; Skelton, J; Squares, S; Stevens, K; Taylor, K; Whitehead, S; Woodward, J. R; Barrell, B. G Title: Massive gene decay in the leprosy bacillus ..- Source: s.l; s.n; feb. 2001. 5 p. ilus, tab, graf. Descriptors: TATUS DNA BACTERIANO METABOLISMO ENERGÉTICO EVOLUÇAO MOLECULAR GENOMA BACTERIANO HANSENIASE DADOS DE SEQUENCIA MOLECULAR GENES REITERADOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANALISE DE SEQUENCIA DE DNA Transferência Genética Horizontal Limits: ANIMAL Location: BR191.1; 08699/s

8 / 12

HANSEN

select to print

Id: 11681 Author: Rambukkana, Anura Title: M. leprae genome sequence ..- Source: s.l; s.n; 2001. 1 p. . Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE SEQUENCIA DE BASES GENOMA BACTERIANO ANALISE DE SEQUENCIA DE DNA Location: BR191.1; 08473/s

9 / 12

HANSEN

select to print

Id: 11472 Author: Dockrell, Hazel M; Brahmbhatt, Shweta; Robertson, Brian D; Britton, Sven; Fruth, Uli; Gebre, Negussie; Hunegnaw, Mesfin; Hussain, Rabia; Manandhar, Rakesh; Murillo, Luis; Pessolani, Maria Cristina V; Roche, Paul; Salgado, Jorge L; Sampaio, Elizabeth; Shahid, Firdaus; Thole, Jelle E. R; Young, Douglas B Title: A postgenomic approach to identification of mycobacterium leprae-specific peptides as T-cell reagents ..- Source: s.l; s.n; 2000. 10 p. tab, graf. Descriptors: HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T GENOMA BACTERIANO ANTIGENOS HLA-DR ANTIGENOS HLA-DR TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PEPTIDIOS PEPTIDIOS ESPECIFICIDADE DE ESPÉCIES LINFOCITOS T Location: BR191.1; 08351/s

10 / 12

HANSEN

select to print

Id: 11455 Author: Skamene, Emil; Schurr, Erwin; Gros, Philippe Title: Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections ..- Source: s.l; s.n; 1998. 13 p. . Descriptors: ALELOS ANTITUBERCULOSOS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS INFECÇOES BACTERIANAS PROTEINAS DE TRANSPORTE SURTOS DE DOENÇAS SUSCETIBILIDADE A DOENÇA GENOMA BACTERIANO GENOMA HUMANO GENOMA DE PROTOZOARIO LEISHMANIOSE LEISHMANIOSE IMUNIDADE NATURAL LEPROSTATICOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE LIGAÇAO (GENÉTICA) MACROFAGOS PROTEINAS DA MEMBRANA CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS INFECÇOES POR SALMONELLA INFECÇOES POR SALMONELLA TUBERCULOSE TUBERCULOSE TUBERCULOSE TUBERCULOSE Predisposição Genética para Doença Limits: ESTUDO COMPARATIVO ANIMAL Location: BR191.1; 08338/s

11 / 12

HANSEN

select to print

Id: 11438 Author: Cole, S. T; Eigimeier, K; Parkhill, J; James, K. D; Thomson, N. R; Wheeler, P. R; Honoré, N; Garnier, T; Churcher, C; Harris, D; Mungall, K; Basham, D; Brown, D; Chillingworth, T; Connor, R; Davies, R. M; Devlin, K; Duthoy, S; Feltwell, T; Fraser, A; Hamlin, N; Holroyd, S; Hornsby, T; Jagels, K; Lacroix, C; Maclean, J; Moule, S; Murphy, L; Oliver, K; Quail, M. A; Rajandream, M.-A; Rutherford, K. M; Rutter, S; Seeger, K; Simon, S; Simmonds, M; Skelton, J; Squares, R; Stevens, K; Taylor, K; Whitehead, S; Woodward, J. R; Barrell, B. G Title: Masssive gene decay in the leprosy bacillus ..- Source: s.l; s.n; 2001. 5 p. ilus, tab, graf. Descriptors: TATUS METABOLISMO ENERGÉTICO DNA BACTERIANO EVOLUÇAO MOLECULAR GENOMA BACTERIANO HANSENIASE DADOS DE SEQUENCIA MOLECULAR GENES REITERADOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANALISE DE SEQUENCIA DE DNA Transferência Genética Horizontal Location: BR191.1; 08320/s

12 / 12

HANSEN

select to print

Id: 9979 Author: Young, Douglas B; Cole, Stewart T Title: Leprosy, tuberculosis, and the new genetics ..- Source: s.l; s.n; 1993. 6 p. tab. Descriptors: RESISTENCIA MICROBIANA A DROGAS GENOMA BACTERIANO HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS TUBERCULOSE TUBERCULOSE TUBERCULOSE VIRULENCIA Location: BR191.1; 06623/s

---

page 1 de 1

Refine the search

Database : HANSEN

Advanced form

Search for : Free form

		Search	in field
1			WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
2	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
3	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type

Search engine: iAH powered by WWWISIS

IAH - © BIREME/PAHO/WHO Latin American and Caribbean Center on Health Sciences Information